Video guide
One hormone, at least five body systems. Muscle or joint pain climbs from 40% before perimenopause to 57% during it, and persistent mood symptoms rise from 8–12% to 14.9–18.4%.
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One hormone. At least five body systems.
Estrogen plays a part in focus, circulation, skin collagen and moisture, muscle strength and bone density. In perimenopause, muscle or joint pain is reported by 57% of women (40% before), and persistent mood symptoms rise from 8–12% to 14.9–18.4%. Estrogen rises and falls erratically, so it helps to track the whole picture, not one symptom at a time.
Estrogen affects brain function including focus, circulation and blood flow, skin collagen and moisture, muscle mass and strength, and bone density.
Cleveland Clinic, EstrogenMuscle or joint pain: 40% before, 57% during perimenopause, 59% after.
Kruse et al., JBJS Open Access, 2026 (review of 37 studies, 93,021 women)Persistent mood symptoms: 8–12% in premenopause vs 14.9–18.4% in early perimenopause.
Bromberger et al., American Journal of Epidemiology, 2003 (SWAN)In perimenopause, estrogen rises and falls erratically.
Cleveland Clinic, PerimenopauseCleveland Clinic, Estrogen
Read the sourceKruse et al. JBJS Open Access, 2026. Systematic review of 37 studies, 93,021 women.
Read the sourceBromberger JT et al. Persistent mood symptoms in a multiethnic community cohort of pre- and perimenopausal women. Am J Epidemiol 2003;158:347-356.
Read the sourceCleveland Clinic, Perimenopause
Read the sourceNumbers are rounded the way the original source reports them. If you spot an error, email admin@svarene.com and we will correct it.
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